Formulation and evaluation of ocular drops containing solid dispersion of tobramycin

نویسندگان

چکیده

Tobramycin is a potent antimicrobial aminoglycoside that can be used to treat ocular infections. Its solubility and bioavailability are limited, so its solid dispersion was prepared using PVP-K30, HPMC Beta cyclodextrin by solvent evaporation technique. This formulated as an eye drop sodium chloride, EDTA benzalkonium chloride. Totally 9 formulations were prepared. The in-vitro dissolution profile of optimised formulation (F6) showed 85.1% drug release at the end 2nd hour. optimized formula evaluated which no microbial growth, content uniformity 80.12% 85%. for clarity, pH, isotonicity, stability in vitro diffusion studies all these acceptable results.

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ژورنال

عنوان ژورنال: Research in pharmacy

سال: 2022

ISSN: ['2231-539X']

DOI: https://doi.org/10.25081/rip.2022.v12.7557